Autacoids & Nsaids

Antihistamines 

A. Histamine and Antihistamines

1. The student shall describe the location and action of histamine and effects of histamine released in humans.

2. The student shall recognize the difference between first and second-generation antihistamines, including the therapeutic uses, and side effects.

3. The student shall recognize some of the unique attributes among the drugs in the antihistamine class.

Prostaglandins and other Autacoids

NSAIDS and other Antirheumatic

A. The student shall recognize the chemistry, synthesis, systemic/organ effects, mechanism of activity, for prostaglandins.

B. The student shall understand the role of COXII and the drugs that inhibit it.

C. The student shall be able to describe the absorption, metabolism and excretion, systemic and organ specific effects and toxicity of salicylates, acetaminophen, proprionic acid derivatives, non-acetylated salicylates, acetic acid derivatives, and anthranilic acid derivatives.

D. The student shall be able to describe the absorption, metabolism and excretion, systemic and organ specific effects and toxicity Piroxicam, etodolac, nabumetone, oxaprozin, COX II inhibitors, and disease modifying antirheumatic drugs.

Gene Therapy and Drugs for Gout

A. The student shall be able to describe gene therapy with regards to methods of gene transfer, treatment goals, and disease targets.

B. The student shall demonstrate knowledge of the chemistry, mechanism of action, pharmacokinetics, therapeutic uses and major toxicity of colchicines.

C. The student shall be able to describe the role of non-steroidal anti-inflammatory drugs in the treatment of gout.

D. The student shall describe the chemistry, mechanism of action, therapeutic uses and major toxic effects of probenecid, sulfinpyrazone, and allopurinol.