Chemotherapy

CHEMOTHERAPY

Anti-infective Drugs I, II

A. Antimicrobial Drugs:

1. The student shall appreciate the general concepts of mechanism of actions, choice of antibiotics, spectrum of activity and resistance, antibiotic combinations, antibiotic prophylaxis, pharmacokinetics and toxicity.

2. The student shall be able to describe the chemistry, mechanism of action, resistance, pharmacokinetics, toxicity and therapeutic uses for sulfonamides, trimethoprim-sulfamethoxazole, penicillins, cephalosporins, other beta-lactam antibiotics, vancomycin, aminoglycosides, tetracyclines, chloramphenicol, macrolides and ketolides, clindamycin, spectinomycin, streptogramins, oxazolidinones, fosfomycin, bacitracin, metronidazole, fluoroquinolones, cyclic lipopeptides, polymyxins, and urinary tract antiseptics.

Anti-infective Drugs III

A. Anti-mycobacterial drugs

1. The student shall be able to describe the chemistry, mechanism of action, resistance, pharmacokinetics, toxicity and therapeutic uses for isoniazid, ethambutol, rifamycins, pyrazinamide, sulfones, and clofazimine.

2. The student shall become familiar with the treatment regime for tuberculosis and leprosy.

B. Antifungal agents

1. The student shall be able to describe the chemistry, mechanism of action, resistance, pharmacokinetics, toxicity and therapeutic uses for amphotericin B, flucytosine, imidazoles and triazoles, echinocandins and griseofulvin.

Anti-infective Drugs IV

A. Antiprotozoal Agents:

1. The student shall be able to describe the chemistry, mechanism of action, pharmacokinetics, toxicity and therapeutic uses for antimalarials including 4-aminoquinolines, 8- aminoquinolines, quinine/quinidine, proguanil, diaminpyrimidines, 4-quinoline-methanols, artemisinin, atovaquone,

2. The student shall be familiar with the recommended treatment for malaria.

B. Antihelmintics

1. The student shall become familiar with the various types of nematodes, trematodes, and cestodes.

2. The student shall be able to describe the mechanism of action, toxicity and therapeutic uses for mebednazole, albendazole, thiabendazole, pyrantel pamoate, diethylcarbamazine, praziquantel, and ivermectin.

3. The student shall become familiar with common protozoa infections in the United States and be able to describe the mechanism of action, toxicity and therapeutic uses for nitroimidazoles, amebicides, and nitazoxanide.

4. The student shall become familiar with major tropical protozoa infections and their treatments.