Endocrine

ENDOCRINE DRUGS

Insulin and Oral Hypoglycaemics; Pituitary

A. The students shall be able to describe the chemistry and production, pharmacokinetics, physiological actions, therapeutic uses, toxicity or abnormal production of: Insulin, amylin analogs, incretins, sulfonylureas, meglitinides, Biguanides, thiazolidinediones, alpha-glucosidase inhibitors, glucagon and somatostatin.

B. The student shall understand the relationship between hypothalamic and pituitary hormones.

C. The student shall demonstrate knowledge on the chemistry and production, mechanism of action and physiological actions, major therapeutic uses, and toxicities for growth hormone, growth hormone antagonists, somatostatins, and prolactin.

Gonadal and Uterine Drugs

A. Reproductive endocrinology and pharmacology

1. The student shall be able to describe the chemistry and physiological actions, side effects, therapeutic uses, and toxicities of the following: GnRH, GnRH agonists and antagonists, gonadotropins, antiestrogens, progestins, antiprogestins, androgens, antiandrogens, and phospdiesterase inhibitors.

B. Pituitary Hormones

1. The student shall understand the preparation, mechanism of action, and toxic effects of oral contraception.

C. Adverse Drug Effects-Teratogenesis

1. The student shall understand the five risk categories of teratogenes, and factors determining teratogenicity, and recognize drugs known as teratogens.

D. The student shall be able to describe the mechanism, pharmacokinetics, effectiveness, side effects, contraindications, precautions, and drug interactions for erectile dysfunction medications such as sildenafil.

Thyroid and Antithyroid Drugs; Calcium

A. The student shall be able to describe the chemistry and physiological actions and toxicity of TSH, TRH and thyroid hormones.

B. The student shall be able to describe the chemistry and mechanism of actions, toxic effects, and therapeutic uses of ionic inhibitors, iodide, and radioactive iodine.

C. The student shall be able to demonstrate knowledge of the chemistry and production, physiological actions, therapeutic uses, toxicity or abnormal production of parathyroid hormone, calcimimetics, Vitamin D, calcitonin, and biphosphates.

D. The student shall recognize other pharmacological agents affecting calcium metabolism.

Corticosteroids

A. The student shall be able to describe the chemistry and physiological actions, therapeutic uses, and toxicity of ACTH, mineralcorticoids, glucocorticoids, and adrenal cortical inhibitors.